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A picture of Dr. Michael J Hamann 

Dr Michael J Hamann

Associate Professor

Biology

Office: S 218M

Phone: (218) 755-2798

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Faculty member in Biology Department since 2007.

Courses Regularly Taught

  • Genetics  
  • Immunology
  • Cell Biology
  • Hematology
  • Advanced Projects

Education

  • Bemidji State University, B.S. Env. Studies, B.A. English
  • Iowa State University, Ph.D. Biochemistry
  • Postdoctoral work at Mayo Clinic

Research

My research interests center around a category of cellular proteins called Rho-family GTPases.  These GTPases participate in events that control cell movement and shape. Besides controlling cellular migration, Rho GTPases frequently act as signaling nodes within cells, and they participate in a wide variety of cellular events through their interactions with a series of upstream and downstream effector proteins. In particular, guanine nucleotide exchange factors (GEFs) play a critical role in events that stimulate the signaling function of GTPases.

Recent publications include:

Ham, H., Guerrier, S., Kim, J., Schoon, R.A., Anderson, E.L., Hamann, M.J., Lou, Z., and Billadeau, D.D. (2013). Dedicator of cytokinesis 8 interacts with talin and Wiskott-Aldrich syndrome protein to regulate NK cell cytotoxicity. J. Immunol. 190, 3661–3669.

Anderson, E.L., and Hamann, M.J. (2012). Detection of Rho GEF and GAP activity through a sensitive split luciferase assay system. Biochem. J. 441, 869–879.

Hamann, M.J., Lubking, C.M., Luchini, D.N., and Billadeau, D.D. (2007). Asef2 functions as a Cdc42 exchange factor and is stimulated by the release of an autoinhibitory module from a concealed C-terminal activation element. Mol. Cell. Biol. 27, 1380–1393.