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Faculty member in Biology Department since 2007.

Courses Regularly Taught

• Genetics
• Molecular Genetics
• Immunology
• Cell Biology
• Advanced Projects

Education

• Bemidji State University, B.S. Env. Studies, B.A. English
  
• Iowa State University, Ph.D. Biochemistry
• Postdoctoral work at Mayo Clinic

Research

Dr. Michael Hamann: My research interests include cellular motility and how low molecular weight GTPases participate in events that control cell movement and shape. Besides controlling migration, GTPases frequently act as signaling nodes within cells, and they participate in a wide variety of cellular events through their interactions with a series of upstream and downstream effector proteins. Understanding their function could provide the basis for developing anti-metastatics, compounds that could inhibit cell migration and metastasis in cancer.

Recent publications include:

Hamann MJ, Lubking CM, Luchini DN, Billadeau DD. Asef2 functions as a Cdc42 exchange factor and is stimulated by the release of an autoinhibitory module from a concealed C-terminal activation element. Mol Cell Biol. 2007 Feb;27(4):1380-93

Miletic AV, Sakata-Sogawa K, Hiroshima M, Hamann MJ, Gomez TS, Ota N, Kloeppel T, Kanagawa O, Tokunaga M, Billadeau DD, Swat W. Vav1 acidic region tyrosine 174 is required for the formation of T cell receptor-induced microclusters and is essential in T cell development and activation. J. Biol. Chem. 2006 Dec 15;281(50):38257-65

Gomez TS, Hamann MJ, McCarney S, Savoy DN, Lubking CM, Heldebrant MP, Labno CM, McKean DJ, McNiven MA, Burkhardt JK, Billadeau DD. Dynamin 2 regulates T cell activation by controlling actin polymerization at the immunological synapse. Nat Immunol. 2005 Mar;6(3):261-70.