Dr Michael Hamann

Associate Professor

Biology

Office: S

Phone: (218) 755-2798

Box #: 27

Email: mhamann@bemidjistate.edu

Degrees

  • Bemidji State University
    BS in Environmental Studies, BA in English
  • Iowa State University
    PhD in Biochemistry
  • Mayo Clinic
    Postdoctoral work

Teaching

  • Genetics
  • Immunology
  • Cell Biology
  • Hematology
  • Advanced Projects

Research Interests

My research interests center around a category of cellular proteins called Rho-family GTPases. These GTPases participate in events that control cell movement and shape. Besides controlling cellular migration, Rho GTPases frequently act as signaling nodes within cells, and they participate in a wide variety of cellular events through their interactions with a series of upstream and downstream effector proteins. In particular, guanine nucleotide exchange factors (GEFs) play a critical role in events that stimulate the signaling function of GTPases.

Recent Work

Ham, H., Guerrier, S., Kim, J., Schoon, R.A., Anderson, E.L., Hamann, M.J., Lou, Z., and Billadeau, D.D. (2013). Dedicator of cytokinesis 8 interacts with talin and Wiskott-Aldrich syndrome protein to regulate NK cell cytotoxicity. J. Immunol. 190, 3661–3669.

Anderson, E.L., and Hamann, M.J. (2012). Detection of Rho GEF and GAP activity through a sensitive split luciferase assay system. Biochem. J. 441, 869–879.

Hamann, M.J., Lubking, C.M., Luchini, D.N., and Billadeau, D.D. (2007). Asef2 functions as a Cdc42 exchange factor and is stimulated by the release of an autoinhibitory module from a concealed C-terminal activation element. Mol. Cell. Biol. 27, 1380–1393.

Bio

Faculty member in Biology Department since 2007.