Dr Michael Hamann

Photo of Dr Michael Hamann

Professor

Office/Department: Biology

Location: Sattgast Hall 218M

Phone: (218) 755-2798

Box #: 27

Email: mhamann@bemidjistate.edu

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Bio

Faculty member in Biology Department since 2007.

 

Degrees

  • Bemidji State University
    BS in Environmental Studies, BA in English
  • Iowa State University
    PhD in Biochemistry
  • Mayo Clinic
    Postdoctoral work

Teaching

  • Genetics
  • Immunology
  • Cell Biology
  • Hematology
  • Advanced Projects

Research Interests

My research interests center around a category of cellular proteins called Rho-family GTPases. These GTPases participate in events that control cell movement and shape. Besides controlling cellular migration, Rho GTPases frequently act as signaling nodes within cells, and they participate in a wide variety of cellular events through their interactions with a series of upstream and downstream effector proteins. In particular, guanine nucleotide exchange factors (GEFs) play a critical role in events that stimulate the signaling function of GTPases.

Recent Work

Florke, R. R., Young, G. T.,  and Hamann, M. J. (2017) Unraveling a model of TCL/RhoJ allosterism using TC10/TCL chimeras. Small GTPases (in review)

Ackermann, K. L., Florke, R. R., Reyes, S. S., Tader, B. R., and Hamann, M. J. (2016) TCL/RhoJ plasma membrane localization and nucleotide exchange is coordinately regulated by amino acids within the N terminus and a distal loop region. J. Biol. Chem. 291, 23604–23617

Ham, H., Guerrier, S., Kim, J., Schoon, R.A., Anderson, E.L., Hamann, M.J., Lou, Z., and Billadeau, D.D. (2013). Dedicator of cytokinesis 8 interacts with talin and Wiskott-Aldrich syndrome protein to regulate NK cell cytotoxicity. J. Immunol. 190, 3661–3669.

Anderson, E.L., and Hamann, M.J. (2012). Detection of Rho GEF and GAP activity through a sensitive split luciferase assay system. Biochem. J. 441, 869–879.